AUTS2

Across TCGA patient cohorts, AUTS2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AUTS2-associated genes across cancer lineages are ATM, eEF2, and PCNA. Each is linked with AUTS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both AUTS2-to-partner and partner-to-AUTS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by AUTS2-low versus AUTS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AUTS2→partner) and Y-score (partner→AUTS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.666	-2.000	<.001	<.001	3	4
COAD	eEF2 →	+0.355	+2.593	.004	.006	3	3
COAD	PCNA →	+0.212	+1.882	.041	.031	3	3
COAD	Caspase-7-cleavedD198 →	+0.834	+3.016	.011	.018	3	3
UCEC	Src_pY527 →	-0.266	-1.237	.030	.041	3	3
UCEC	Cyclin-B1 →	+0.480	+2.087	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

ATM by AUTS2 expression — UCEC

Explore this box plot interactively →