AUTS2

Across TCGA cell cohorts, AUTS2 mutation is significantly associated with the RNA expression of many other genes, with 736 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AUTS2-associated genes across cancer lineages are C3orf85, KRT28, and MS4A7. Each is linked with AUTS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AUTS2-to-partner and partner-to-AUTS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C3orf85 grouped by AUTS2-low versus AUTS2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AUTS2→partner) and Y-score (partner→AUTS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	C3orf85 →	+0.132	+5.000	<.001	.006	3	2
OVARY	KRT28 →	+0.065	+4.029	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	MS4A7 →	+0.053	+3.959	<.001	.001	3	2
LUNG_SCLC	CLPS →	+0.076	+3.169	<.001	.005	3	2
BLOOD_Leukemia	DNAH10OS →	+0.805	+3.231	<.001	.007	3	2
LUNG_NSCLC_LUAD	TAF8 →	+0.489	+3.206	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 736 associations by consensus.

C3orf85 by AUTS2 expression — PANCREAS

Explore this box plot interactively →