AURKB

Across TCGA pan-cancer cohorts, AURKB mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated AURKB data layer compared with 32 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher AURKB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AURKB expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, LSCC, and HNSC are the cancer types where AURKB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.184	0.875	.006	32	view →
LSCC	OS	Tertile	All	0.974	0.740	.002	24	view →
HNSC	DFS	Quartile	All	0.585	0.985	.026	5	view →
UCEC	DFS	Median	All	0.764	0.941	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

AURKB–PDAC (DFS)

Open the PDAC breakdown →