AURKB

Across TCGA patient cohorts, AURKB mutation is significantly associated with the RNA expression of many other genes, with 312 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AURKB-associated genes across cancer lineages are IGKV3D-34, RNU4-31P, and NDUFA5P1. Each is linked with AURKB in more than 1 cancer types. Because this analysis shows association rather than direction, both AURKB-to-partner and partner-to-AURKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGKV3D-34 grouped by AURKB-low versus AURKB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AURKB→partner) and Y-score (partner→AURKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGKV3D-34 →	+0.111	+5.332	.001	.002	3	2
BLCA	RNU4-31P →	+0.391	+4.396	<.001	.006	3	2
UCEC	NDUFA5P1 →	+0.139	+3.098	<.001	.002	3	2
STAD	RN7SL557P →	+0.269	+4.078	.008	.002	3	2
UCEC	MPPE1 →	+0.535	+3.212	.003	.009	3	1
UCEC	SEPTIN14 →	+0.470	+2.575	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 312 associations by consensus.

IGKV3D-34 by AURKB expression — COAD

Explore this box plot interactively →