AURKB

Across TCGA patient cohorts, AURKB mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AURKB-associated genes across cancer lineages are DJ-1, eIF4E, and Fibronectin. Each is linked with AURKB in more than 1 cancer types. Because this analysis shows association rather than direction, both AURKB-to-partner and partner-to-AURKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DJ-1 grouped by AURKB-low versus AURKB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AURKB→partner) and Y-score (partner→AURKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DJ-1 →	+0.176	+2.321	.036	.035	3	2
UCEC	eIF4E →	+0.210	+3.459	.047	.005	3	1
UCEC	Fibronectin →	-0.386	-2.321	.019	.035	3	1
UCEC	MEK1 →	+0.437	+3.169	.017	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.265	+2.335	.010	.020	3	1
UCEC	Myosin-IIa →	+0.236	+3.010	.011	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

DJ-1 by AURKB expression — UCEC

Explore this box plot interactively →