AURKA

Across TCGA pan-cancer cohorts, AURKA mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated AURKA data layer compared with 29 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AURKA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AURKA expression acts as an unfavorable survival marker.

HNSC and PDAC are the cancer types where AURKA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.264	0.886	.002	44	view →
PDAC	OS	Median	All	0.264	0.690	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

AURKA–HNSC (DFS)

Open the HNSC breakdown →