AURKA

Across TCGA patient cohorts, AURKA protein abundance is significantly associated with the RNA expression of many other genes, with 12,857 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible AURKA-associated genes across cancer lineages are FOXM1, UBE2C, and MYBL2. Each is linked with AURKA in more than 7 cancer types. Because this analysis shows association rather than direction, both AURKA-to-partner and partner-to-AURKA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AURKA versus FOXM1 in LUAD, with a Pearson correlation of 0.80.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AURKA→partner) and Y-score (partner→AURKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FOXM1 →	+1.558	+0.952	<.001	<.001	3	8
LUAD	UBE2C →	+2.523	+0.893	<.001	<.001	3	8
LUAD	MYBL2 →	+2.162	+0.904	<.001	<.001	3	7
LUAD	FAM83D →	+1.536	+0.809	<.001	<.001	3	7
UCEC	OIP5 →	+0.847	+0.878	<.001	<.001	3	7
UCEC	NEIL3 →	+1.291	+0.885	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,857 associations by consensus.

AURKA vs FOXM1 — LUAD

Explore this scatter interactively →