AURKA

Across TCGA patient cohorts, AURKA mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AURKA-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and c-Met_pY1235. Each is linked with AURKA in more than 1 cancer types. Because this analysis shows association rather than direction, both AURKA-to-partner and partner-to-AURKA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by AURKA-low versus AURKA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AURKA→partner) and Y-score (partner→AURKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.186	-2.999	.022	.035	3	1
UCEC	Ku80 →	+0.324	+2.472	.004	.011	3	1
UCEC	c-Met_pY1235 →	+0.089	+3.179	.012	.010	3	1
UCEC	p62 Lck ligand →	+0.377	+3.009	.016	.019	2	1
UCEC	Beclin →	+0.091	+2.459	.045	.020	2	1
UCEC	4E-BP1_pT37_T46 →	-0.647	-2.459	<.001	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK_pT183_Y185 by AURKA expression — UCEC

Explore this box plot interactively →