AURKA

Across TCGA cell cohorts, AURKA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,654 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AURKA-associated GO terms across cancer lineages are Positive regulation of chromosome separation, Positive regulation of cell cycle, and Chromosome localization. Each is linked with AURKA in more than 18 cancer types. Because this analysis shows association rather than direction, both AURKA-to-partner and partner-to-AURKA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of chromosome separation grouped by AURKA-low versus AURKA-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AURKA→partner) and Y-score (partner→AURKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of chromosome separation →	+0.210	+1.648	<.001	<.001	3	19
OESOPHAGUS	Positive regulation of cell cycle →	+0.086	+1.601	.006	.001	3	19
OESOPHAGUS	Chromosome localization →	+0.139	+1.383	.005	.009	3	19
KIDNEY	Metaphase chromosome alignment →	+0.132	+1.434	<.001	<.001	3	19
SOFT_TISSUE	Protein localization to condensed chromosome →	+0.183	+1.368	<.001	<.001	3	19
OESOPHAGUS	Nuclear chromosome segregation →	+0.147	+1.581	.003	.003	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,654 associations by consensus.

Positive regulation of chromosome separation by AURKA expression — PANCREAS

Explore this box plot interactively →