AUP1

Across TCGA patient cohorts, AUP1 mutation is significantly associated with the RNA expression of many other genes, with 2,316 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AUP1-associated genes across cancer lineages are TRAJ12, LYZL2, and KCNK18. Each is linked with AUP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AUP1-to-partner and partner-to-AUP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ12 grouped by AUP1-low versus AUP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AUP1→partner) and Y-score (partner→AUP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ12 →	+1.033	+3.818	.006	.009	3	3
SCLC	LYZL2 →	+0.314	+4.847	<.001	.009	3	2
SCLC	KCNK18 →	+0.056	+5.189	.003	.006	3	2
UCEC	SNRPGP17 →	+0.237	+2.615	.005	<.001	3	2
UCEC	MIR7702 →	+0.229	+4.253	<.001	.004	3	2
UCEC	PSMB7 →	+0.396	+3.640	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,316 associations by consensus.

TRAJ12 by AUP1 expression — COAD

Explore this box plot interactively →