AUP1

Across TCGA patient cohorts, AUP1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AUP1-associated genes across cancer lineages are PCNA, MEK1, and Notch1. Each is linked with AUP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AUP1-to-partner and partner-to-AUP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by AUP1-low versus AUP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AUP1→partner) and Y-score (partner→AUP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.245	+2.459	.019	.020	3	2
UCEC	MEK1 →	+0.460	+3.321	.009	.010	3	1
UCEC	Notch1 →	+0.187	+2.459	.005	.020	3	1
UCEC	PDCD4 →	-0.564	-2.459	.013	.020	3	1
UCEC	Annexin-1 →	+0.717	+3.019	.004	.019	3	1
UCEC	VHL →	-0.809	-3.000	.013	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PCNA by AUP1 expression — UCEC

Explore this box plot interactively →