ATXN8OS

Across TCGA patient cohorts, ATXN8OS mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATXN8OS-associated genes across cancer lineages are OR6K6, RNU6-1082P, and TRGJP2. Each is linked with ATXN8OS in more than 1 cancer types. Because this analysis shows association rather than direction, both ATXN8OS-to-partner and partner-to-ATXN8OS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6K6 grouped by ATXN8OS-low versus ATXN8OS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN8OS→partner) and Y-score (partner→ATXN8OS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR6K6 →	+0.215	+5.943	<.001	<.001	3	1
UCEC	RNU6-1082P →	+0.610	+4.551	<.001	.009	3	1
UCEC	TRGJP2 →	+1.396	+4.473	<.001	.005	3	1
UCEC	RN7SL191P →	+0.627	+5.666	<.001	<.001	3	1
UCEC	SNRPGP7 →	+0.711	+5.335	<.001	.003	3	1
UCEC	RN7SL454P →	+0.551	+4.423	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

OR6K6 by ATXN8OS expression — UCEC

Explore this box plot interactively →