ATXN7L3B

Across TCGA patient cohorts, ATXN7L3B mutation is significantly associated with the RNA expression of many other genes, with 3,124 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATXN7L3B-associated genes across cancer lineages are RPL7P40, CYCSP22, and ISCA1P3. Each is linked with ATXN7L3B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATXN7L3B-to-partner and partner-to-ATXN7L3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL7P40 grouped by ATXN7L3B-low versus ATXN7L3B-high in KIRP.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN7L3B→partner) and Y-score (partner→ATXN7L3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	RPL7P40 →	+0.082	+5.628	<.001	.004	3	2
READ	CYCSP22 →	+0.206	+5.421	<.001	.005	3	2
READ	ISCA1P3 →	+0.184	+5.039	<.001	.008	3	2
LIHC	RPS10P21 →	+0.087	+5.544	<.001	.004	3	2
UCEC	FKBP3 →	+0.535	+3.595	.001	.001	3	2
UCEC	POLE2 →	+0.496	+2.828	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,124 associations by consensus.

RPL7P40 by ATXN7L3B expression — KIRP

Explore this box plot interactively →