ATXN7L3B

Across TCGA patient cohorts, ATXN7L3B mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATXN7L3B-associated genes across cancer lineages are PCNA, EGFR_pY1068, and Stathmin. Each is linked with ATXN7L3B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATXN7L3B-to-partner and partner-to-ATXN7L3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ATXN7L3B-low versus ATXN7L3B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN7L3B→partner) and Y-score (partner→ATXN7L3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.290	+2.815	.033	.036	3	2
UCEC	EGFR_pY1068 →	-0.260	-2.247	.004	.001	3	2
UCEC	Stathmin →	+0.123	+1.502	.014	.030	3	2
UCEC	ASNS →	+0.377	+2.222	.004	.010	3	2
UCEC	eIF4E →	+0.158	+3.183	.040	.009	3	1
UCEC	A-Raf_pS299 →	-0.175	-3.906	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PCNA by ATXN7L3B expression — COAD

Explore this box plot interactively →