ATXN7L2

Across TCGA patient cohorts, ATXN7L2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATXN7L2-associated genes across cancer lineages are PTEN, Acetyl-a-Tubulin-Lys40, and PDCD4. Each is linked with ATXN7L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATXN7L2-to-partner and partner-to-ATXN7L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTEN grouped by ATXN7L2-low versus ATXN7L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN7L2→partner) and Y-score (partner→ATXN7L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTEN →	-0.318	-2.999	.047	.035	3	3
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.721	+2.000	.003	.031	3	2
SKCM	PDCD4 →	-0.586	-2.000	.001	.031	3	2
UCEC	Caspase-8 →	-0.270	-2.880	.007	.001	3	2
UCEC	Notch1 →	+0.196	+1.594	<.001	.042	3	2
UCEC	ATM →	-0.749	-3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PTEN by ATXN7L2 expression — UCEC

Explore this box plot interactively →