ATXN7L2

Across TCGA cell cohorts, ATXN7L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,382 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ATXN7L2-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Negative regulation of gene expression, epigenetic, and Positive regulation of double-strand break repair via homologous recombination. Each is linked with ATXN7L2 in more than 15 cancer types. Because this analysis shows association rather than direction, both ATXN7L2-to-partner and partner-to-ATXN7L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by ATXN7L2-low versus ATXN7L2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN7L2→partner) and Y-score (partner→ATXN7L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Epigenetic regulation of gene expression →	+0.081	+1.193	<.001	<.001	3	16
STOMACH	Negative regulation of gene expression, epigenetic →	+0.090	+0.893	<.001	.005	3	15
OVARY	Positive regulation of double-strand break repair via homologous recombination →	+0.081	+0.817	<.001	<.001	3	15
LIVER	DNA topological change →	+0.150	+1.220	.002	<.001	3	15
STOMACH	Heterochromatin formation →	+0.090	+0.912	.001	.005	2	15
BLOOD_Myeloma	IMP biosynthetic process →	+0.169	+0.762	<.001	.005	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,382 associations by consensus.

Epigenetic regulation of gene expression by ATXN7L2 expression — STOMACH

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