ATXN7L2

Across TCGA cell cohorts, ATXN7L2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATXN7L2-associated genes across cancer lineages are OR4F4, ELOA3DP, and H4C13. Each is linked with ATXN7L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATXN7L2-to-partner and partner-to-ATXN7L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F4 grouped by ATXN7L2-low versus ATXN7L2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN7L2→partner) and Y-score (partner→ATXN7L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F4 →	+0.016	+3.688	<.001	.002	3	1
LARGE_INTESTINE	ELOA3DP →	+0.027	+3.688	<.001	.002	3	1
LARGE_INTESTINE	H4C13 →	+0.320	+3.592	.001	.006	3	1
LARGE_INTESTINE	H2BC3 →	+0.203	+3.196	<.001	.007	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1
CNS	HES3 →	+0.032	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

OR4F4 by ATXN7L2 expression — LARGE_INTESTINE

Explore this box plot interactively →