ATXN7L1

Across TCGA patient cohorts, ATXN7L1 mutation is significantly associated with the RNA expression of many other genes, with 3,440 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATXN7L1-associated genes across cancer lineages are POLDIP3, KIAA0930, and ZC3H14. Each is linked with ATXN7L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATXN7L1-to-partner and partner-to-ATXN7L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLDIP3 grouped by ATXN7L1-low versus ATXN7L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN7L1→partner) and Y-score (partner→ATXN7L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLDIP3 →	+0.612	+2.315	<.001	<.001	3	2
UCEC	KIAA0930 →	+0.338	+2.743	.002	.002	3	2
UCEC	ZC3H14 →	+0.333	+3.130	.001	<.001	3	2
UCEC	TLE6 →	+0.699	+1.776	<.001	<.001	3	2
UCEC	TRIM16L →	+0.613	+2.153	<.001	<.001	3	2
UCEC	RAI1 →	+0.632	+2.595	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,440 associations by consensus.

POLDIP3 by ATXN7L1 expression — UCEC

Explore this box plot interactively →