ATXN7L1

Across TCGA cell cohorts, ATXN7L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,625 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ATXN7L1-associated GO terms across cancer lineages are Endoplasmic reticulum-plasma membrane tethering, Positive regulation of isotype switching to IgG isotypes, and Regulation of autophagosome maturation. Each is linked with ATXN7L1 in more than 7 cancer types. Because this analysis shows association rather than direction, both ATXN7L1-to-partner and partner-to-ATXN7L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum-plasma membrane tethering grouped by ATXN7L1-low versus ATXN7L1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN7L1→partner) and Y-score (partner→ATXN7L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Endoplasmic reticulum-plasma membrane tethering →	+0.195	+0.665	<.001	<.001	3	8
BONE	Positive regulation of isotype switching to IgG isotypes →	+0.136	+1.103	<.001	<.001	3	7
BONE	Regulation of autophagosome maturation →	+0.091	+0.874	<.001	.007	3	7
BONE	Regulation of membrane tubulation →	+0.126	+0.968	<.001	<.001	3	7
BONE	Vesicle docking →	+0.077	+0.974	<.001	.005	2	7
STOMACH	Pyrimidine nucleotide-sugar transmembrane transport →	+0.099	+0.859	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,625 associations by consensus.

Endoplasmic reticulum-plasma membrane tethering by ATXN7L1 expression — BREAST

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