ATXN7L1

Across TCGA cell cohorts, ATXN7L1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible ATXN7L1-associated genes across cancer lineages are SEC14L3, GJA8, and SHCBP1L. Each is linked with ATXN7L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATXN7L1-to-partner and partner-to-ATXN7L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC14L3 grouped by ATXN7L1-low versus ATXN7L1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN7L1→partner) and Y-score (partner→ATXN7L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SEC14L3 →	+0.011	+4.217	<.001	.005	3	1
URINARY_TRACT	GJA8 →	+0.015	+4.087	<.001	.009	3	1
URINARY_TRACT	SHCBP1L →	+0.042	+4.087	.001	.009	3	1
URINARY_TRACT	C3orf22 →	+0.016	+4.584	<.001	.002	3	1
URINARY_TRACT	LRRC3C →	+0.112	+4.584	.002	.002	3	1
URINARY_TRACT	MROH5 →	+0.005	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

SEC14L3 by ATXN7L1 expression — URINARY_TRACT

Explore this box plot interactively →