ATXN7

Across TCGA cell cohorts, ATXN7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,381 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATXN7-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Negative regulation of microtubule depolymerization, and Regulation of sister chromatid cohesion. Each is linked with ATXN7 in more than 15 cancer types. Because this analysis shows association rather than direction, both ATXN7-to-partner and partner-to-ATXN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by ATXN7-low versus ATXN7-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN7→partner) and Y-score (partner→ATXN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of gene expression, epigenetic →	+0.054	+1.005	<.001	.001	3	16
OVARY	Negative regulation of microtubule depolymerization →	+0.130	+0.930	<.001	<.001	3	16
OVARY	Regulation of sister chromatid cohesion →	+0.117	+0.799	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair →	+0.074	+0.868	<.001	<.001	3	16
LARGE_INTESTINE	Regulation of telomere maintenance →	+0.065	+0.865	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Regulation of hippo signaling →	+0.091	+0.607	.002	.005	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,381 associations by consensus.

Negative regulation of gene expression, epigenetic by ATXN7 expression — BREAST

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