ATXN7

Across TCGA cell cohorts, ATXN7 mutation is significantly associated with the RNA expression of many other genes, with 480 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATXN7-associated genes across cancer lineages are OPRM1, SERPINA7, and COX4I2. Each is linked with ATXN7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATXN7-to-partner and partner-to-ATXN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRM1 grouped by ATXN7-low versus ATXN7-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN7→partner) and Y-score (partner→ATXN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OPRM1 →	+0.124	+5.369	<.001	.004	3	1
SOFT_TISSUE	SERPINA7 →	+0.012	+4.930	<.001	.008	3	1
SOFT_TISSUE	COX4I2 →	+0.377	+4.930	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1
BLOOD_Leukemia	ANKRD30BL →	+1.083	+3.874	<.001	.005	3	1
BLOOD_Leukemia	OR4D9 →	+0.003	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 480 associations by consensus.

OPRM1 by ATXN7 expression — SOFT_TISSUE

Explore this box plot interactively →