ATXN2L

Across TCGA patient cohorts, ATXN2L mutation is significantly associated with the RNA expression of many other genes, with 4,727 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATXN2L-associated genes across cancer lineages are RASSF1, KCTD9, and ENO2. Each is linked with ATXN2L in more than 3 cancer types. Because this analysis shows association rather than direction, both ATXN2L-to-partner and partner-to-ATXN2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RASSF1 grouped by ATXN2L-low versus ATXN2L-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN2L→partner) and Y-score (partner→ATXN2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RASSF1 →	+0.610	+3.371	<.001	.004	3	4
STAD	KCTD9 →	+0.896	+3.355	<.001	.005	3	4
UCEC	ENO2 →	+0.707	+1.938	<.001	.001	3	4
UCEC	GOT1 →	+0.382	+3.523	<.001	<.001	3	4
UCEC	EAF1 →	+0.492	+2.321	<.001	<.001	3	4
UCEC	ZSCAN22 →	+0.375	+3.000	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,727 associations by consensus.

RASSF1 by ATXN2L expression — STAD

Explore this box plot interactively →