ATXN2L

Across TCGA patient cohorts, ATXN2L mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATXN2L-associated genes across cancer lineages are Caspase-7-cleavedD198, PDCD4, and Rad50. Each is linked with ATXN2L in more than 4 cancer types. Because this analysis shows association rather than direction, both ATXN2L-to-partner and partner-to-ATXN2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ATXN2L-low versus ATXN2L-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN2L→partner) and Y-score (partner→ATXN2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.182	+3.178	.002	.010	1	5
UCEC	PDCD4 →	-0.399	-1.575	.009	.017	3	3
COAD	Rad50 →	-0.367	-3.000	.002	.034	3	2
UCEC	ACC_pS79 →	+0.297	+1.424	.008	.027	3	2
UCEC	JNK_pT183_Y185 →	-0.183	-2.308	<.001	<.001	3	2
UCEC	p90 RSK →	+0.182	+1.472	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Caspase-7-cleavedD198 by ATXN2L expression — COAD

Explore this box plot interactively →