ATXN2L

Across TCGA cell cohorts, ATXN2L mutation is significantly associated with the RNA expression of many other genes, with 984 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATXN2L-associated genes across cancer lineages are TCP1, SNX27, and PRR30. Each is linked with ATXN2L in more than 2 cancer types. Because this analysis shows association rather than direction, both ATXN2L-to-partner and partner-to-ATXN2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCP1 grouped by ATXN2L-low versus ATXN2L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN2L→partner) and Y-score (partner→ATXN2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TCP1 →	+0.648	+3.949	<.001	<.001	3	3
BLOOD_Leukemia	SNX27 →	+0.484	+3.321	.004	.005	3	3
LUNG_NSCLC_LUAD	PRR30 →	+0.015	+4.189	<.001	.002	3	2
LARGE_INTESTINE	PRPS2 →	+0.474	+3.237	.009	.003	3	2
LARGE_INTESTINE	DTWD1 →	+0.614	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	MAPK8 →	+0.618	+2.331	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 984 associations by consensus.

TCP1 by ATXN2L expression — LARGE_INTESTINE

Explore this box plot interactively →