Across TCGA patient cohorts, ATXN2 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,236 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ATXN2-associated proteins across cancer lineages are TRIM28, SART3, and WDR5. Each is linked with ATXN2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ATXN2-to-partner and partner-to-ATXN2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN2→partner) and Y-score (partner→ATXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRIM28 →	+0.366	+0.499	<.001	<.001	3	6
HNSC	SART3 →	+0.177	+0.536	<.001	<.001	3	6
LSCC	WDR5 →	+0.330	+0.442	<.001	<.001	3	5
LSCC	YTHDC1 →	+0.306	+0.513	<.001	<.001	3	5
LSCC	MBD3 →	+0.552	+0.432	<.001	<.001	3	5
GBM	SNRPD2 →	+0.180	+0.210	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,236 associations by consensus.

Exploration

ATXN2 survival (RNA) · tumor vs normal (RNA) · all ATXN2 data types