Across TCGA patient cohorts, ATXN2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,404 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ATXN2-associated genes across cancer lineages are UBE2N, PGAM5, and ARL1. Each is linked with ATXN2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ATXN2-to-partner and partner-to-ATXN2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN2→partner) and Y-score (partner→ATXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	UBE2N →	+0.424	+0.157	.006	.006	3	5
COAD	PGAM5 →	+0.610	+0.209	<.001	<.001	3	5
BRCA	ARL1 →	+0.403	+0.171	<.001	<.001	3	5
BRCA	PSME3 →	+0.363	+0.150	.001	.002	3	5
UCEC	RITA1 →	+0.800	+0.215	.001	<.001	3	5
LUAD	SUDS3 →	+0.520	+0.321	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,404 associations by consensus.

Exploration

ATXN2 survival (RNA) · tumor vs normal (RNA) · all ATXN2 data types