Across TCGA patient cohorts, ATXN2 mutation is significantly associated with the RNA expression of many other genes, with 5,687 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATXN2-associated genes across cancer lineages are SEC23A-AS1, LINC01893, and RFC5. Each is linked with ATXN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATXN2-to-partner and partner-to-ATXN2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN2→partner) and Y-score (partner→ATXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEC23A-AS1 →	+0.163	+3.662	.002	.003	3	3
BRCA	LINC01893 →	+0.105	+2.815	.007	.008	3	3
UCEC	RFC5 →	+0.554	+2.885	<.001	<.001	3	3
COAD	CA14 →	+0.377	+3.387	<.001	.004	3	3
UCEC	UBR7 →	+0.544	+2.169	<.001	<.001	3	3
UCEC	RPA1 →	+0.569	+1.771	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,687 associations by consensus.

Exploration

ATXN2 survival (RNA) · tumor vs normal (RNA) · all ATXN2 data types