ATRX

Across TCGA patient cohorts, ATRX RNA expression is significantly associated with the protein abundance of many other proteins, with 15,515 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ATRX-associated proteins across cancer lineages are HCFC1, TCEAL1, and PPIF. Each is linked with ATRX in more than 5 cancer types. Because this analysis shows association rather than direction, both ATRX-to-partner and partner-to-ATRX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ATRX versus HCFC1 in LSCC, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ATRX→partner) and Y-score (partner→ATRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HCFC1 →	+0.180	+0.365	<.001	.001	2	6
BRCA	TCEAL1 →	+0.535	+0.443	<.001	<.001	3	5
OV	PPIF →	-0.479	-0.489	.002	.007	3	5
HNSC	HNRNPH2 →	+0.149	+0.332	<.001	.005	3	5
LSCC	NONO →	+0.224	+0.388	<.001	.001	3	5
UCEC	RBM10 →	+0.236	+0.449	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,515 associations by consensus.

ATRX vs HCFC1 — LSCC

Explore this scatter interactively →