ATRX

Across TCGA cell cohorts, ATRX RNA expression is significantly associated with the go_rna of many other GO terms, with 4,889 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATRX-associated GO terms across cancer lineages are Negative regulation of maintenance of sister chromatid cohesion, Negative regulation of maintenance of mitotic sister chromatid cohesion, and Negative regulation of telomere maintenance. Each is linked with ATRX in more than 19 cancer types. Because this analysis shows association rather than direction, both ATRX-to-partner and partner-to-ATRX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of maintenance of sister chromatid cohesion grouped by ATRX-low versus ATRX-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATRX→partner) and Y-score (partner→ATRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of maintenance of sister chromatid cohesion →	+0.169	+1.116	<.001	<.001	3	20
LUNG_SCLC	Negative regulation of maintenance of mitotic sister chromatid cohesion →	+0.169	+1.116	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Negative regulation of telomere maintenance →	+0.084	+0.909	<.001	<.001	3	18
BONE	Regulation of alternative mRNA splicing, via spliceosome →	+0.110	+1.240	<.001	<.001	3	17
BONE	Regulation of sister chromatid cohesion →	+0.109	+0.835	<.001	<.001	3	17
OVARY	U2-type prespliceosome assembly →	+0.118	+1.173	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,889 associations by consensus.

Negative regulation of maintenance of sister chromatid cohesion by ATRX expression — LUNG_SCLC

Explore this box plot interactively →