ATRX

Across TCGA cell cohorts, ATRX mutation is significantly associated with the RNA expression of many other genes, with 1,174 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATRX-associated genes across cancer lineages are RBMXL2, IQCB1, and CYFIP2. Each is linked with ATRX in more than 2 cancer types. Because this analysis shows association rather than direction, both ATRX-to-partner and partner-to-ATRX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMXL2 grouped by ATRX-low versus ATRX-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATRX→partner) and Y-score (partner→ATRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RBMXL2 →	+0.057	+3.179	.002	.002	3	3
LARGE_INTESTINE	IQCB1 →	+0.433	+1.483	.001	.002	3	3
LARGE_INTESTINE	CYFIP2 →	+1.074	+2.222	.001	.001	3	3
PANCREAS	KRT37 →	+0.044	+3.765	<.001	.006	3	2
BLOOD_Lymphoma	PRKACG →	+0.016	+2.655	.002	.002	3	2
BLOOD_Lymphoma	EFCAB1 →	+0.105	+2.758	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,174 associations by consensus.

RBMXL2 by ATRX expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →