ATR

Across TCGA pan-cancer cohorts, ATR mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ATR data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ATR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ATR expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where ATR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.913	.043	12	view →
PDAC	DFS	Median	All	0.471	0.260	.023	4	view →
HNSC	DFS	Median	II,III,IV	0.749	0.574	.039	3	view →
LSCC	DFS	Tertile	II,III,IV	0.881	0.520	.027	2	view →
LUAD	OS	Median	All	0.972	0.914	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ATR–COAD (DFS)

Open the COAD breakdown →