ATR

Across TCGA patient cohorts, ATR mutation is significantly associated with the RNA expression of many other genes, with 7,438 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATR-associated genes across cancer lineages are ZNF367, SCNN1B, and LSM3. Each is linked with ATR in more than 4 cancer types. Because this analysis shows association rather than direction, both ATR-to-partner and partner-to-ATR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF367 grouped by ATR-low versus ATR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATR→partner) and Y-score (partner→ATR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF367 →	+0.800	+2.095	<.001	<.001	3	5
UCEC	SCNN1B →	-0.848	-1.037	.005	.007	3	5
UCEC	LSM3 →	+0.437	+1.519	<.001	<.001	3	5
UCEC	UQCRH →	+0.662	+1.413	<.001	<.001	3	5
UCEC	HMG20B →	+0.503	+2.606	<.001	<.001	3	5
UCEC	COX10 →	+0.443	+1.938	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,438 associations by consensus.

ZNF367 by ATR expression — UCEC

Explore this box plot interactively →