ATR

Across TCGA cell cohorts, ATR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,597 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATR-associated GO terms across cancer lineages are Double-strand break repair, Replication fork processing, and DNA-templated DNA replication maintenance of fidelity. Each is linked with ATR in more than 15 cancer types. Because this analysis shows association rather than direction, both ATR-to-partner and partner-to-ATR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair grouped by ATR-low versus ATR-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATR→partner) and Y-score (partner→ATR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair →	+0.085	+0.826	<.001	<.001	3	16
OESOPHAGUS	Replication fork processing →	+0.152	+0.683	.003	<.001	3	16
OESOPHAGUS	DNA-templated DNA replication maintenance of fidelity →	+0.144	+0.727	.002	<.001	3	16
LUNG_SCLC	Protein localization to chromosome, telomeric region →	+0.109	+0.678	.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	Recombinational repair →	+0.088	+0.852	.001	.001	3	16
OESOPHAGUS	DNA-templated DNA replication →	+0.141	+0.571	.004	.005	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,597 associations by consensus.

Double-strand break repair by ATR expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →