ATR

Across TCGA cell cohorts, ATR mutation is significantly associated with the RNA expression of many other genes, with 1,519 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATR-associated genes across cancer lineages are NOBOX, PGM3, and SYDE2. Each is linked with ATR in more than 2 cancer types. Because this analysis shows association rather than direction, both ATR-to-partner and partner-to-ATR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOBOX grouped by ATR-low versus ATR-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATR→partner) and Y-score (partner→ATR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NOBOX →	+0.015	+2.263	.007	.003	3	3
LARGE_INTESTINE	PGM3 →	+0.875	+3.652	<.001	<.001	3	3
LARGE_INTESTINE	SYDE2 →	+0.621	+3.386	<.001	.001	3	3
BLOOD_Myeloma	SAMD7 →	+0.481	+3.906	.007	.009	3	2
LARGE_INTESTINE	COPS4 →	+0.622	+2.158	.002	.004	3	2
SKIN	OTC →	+0.035	+3.827	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,519 associations by consensus.

NOBOX by ATR expression — LUNG_SCLC

Explore this box plot interactively →