ATPSCKMT

Across TCGA patient cohorts, ATPSCKMT mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATPSCKMT-associated genes across cancer lineages are EGFR_pY1068, JNK2, and p62 Lck ligand. Each is linked with ATPSCKMT in more than 1 cancer types. Because this analysis shows association rather than direction, both ATPSCKMT-to-partner and partner-to-ATPSCKMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ATPSCKMT-low versus ATPSCKMT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATPSCKMT→partner) and Y-score (partner→ATPSCKMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.290	-3.000	.045	.037	3	1
UCEC	JNK2 →	+0.236	+3.000	.040	.037	3	1
UCEC	p62 Lck ligand →	+0.372	+2.817	.048	.036	3	1
UCEC	Ku80 →	+0.314	+3.013	.021	.019	1	1
UCEC	MEK1 →	+0.735	+3.000	<.001	.037	1	1
UCEC	STAT3_pY705 →	-0.485	-3.000	.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

EGFR_pY1068 by ATPSCKMT expression — UCEC

Explore this box plot interactively →