ATPSCKMT

Across TCGA cell cohorts, ATPSCKMT mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATPSCKMT-associated genes across cancer lineages are CPLX4, BPIFB6, and REG1B. Each is linked with ATPSCKMT in more than 1 cancer types. Because this analysis shows association rather than direction, both ATPSCKMT-to-partner and partner-to-ATPSCKMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPLX4 grouped by ATPSCKMT-low versus ATPSCKMT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATPSCKMT→partner) and Y-score (partner→ATPSCKMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CPLX4 →	+0.027	+4.392	.001	.004	3	1
LARGE_INTESTINE	BPIFB6 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	REG1B →	+2.538	+4.196	<.001	.002	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	FREM3 →	+0.159	+4.054	<.001	.004	3	1
OVARY	IDI2 →	+0.018	+4.029	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

CPLX4 by ATPSCKMT expression — LARGE_INTESTINE

Explore this box plot interactively →