ATPAF2

Across TCGA patient cohorts, ATPAF2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATPAF2-associated genes across cancer lineages are INPP4B, VHL, and CD31. Each is linked with ATPAF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATPAF2-to-partner and partner-to-ATPAF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by ATPAF2-low versus ATPAF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATPAF2→partner) and Y-score (partner→ATPAF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.447	-2.999	.011	.035	3	1
UCEC	VHL →	-1.375	-3.169	<.001	.020	3	1
UCEC	CD31 →	-0.175	-3.169	.030	.020	3	1
UCEC	eIF4E →	+0.246	+3.169	.033	.020	2	1
UCEC	eIF4G →	+0.425	+3.169	.012	.020	2	1
UCEC	MEK1 →	+0.519	+3.169	.009	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

INPP4B by ATPAF2 expression — UCEC

Explore this box plot interactively →