ATPAF1

Across TCGA pan-cancer cohorts, ATPAF1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ATPAF1 data layer compared with 18 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ATPAF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ATPAF1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where ATPAF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.999	0.784	.008	18	view →
CCRCC	DFS	Quartile	II,III,IV	0.469	0.840	.011	14	view →
PDAC	OS	Median	II,III,IV	0.764	0.916	.018	6	view →
HNSC	DFS	Quartile	III,IV	0.751	0.474	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ATPAF1–LSCC (DFS)

Open the LSCC breakdown →