ATP9B

Across TCGA patient cohorts, ATP9B mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP9B-associated genes across cancer lineages are Akt_pT308, Rad50, and Caspase-7-cleavedD198. Each is linked with ATP9B in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP9B-to-partner and partner-to-ATP9B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by ATP9B-low versus ATP9B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP9B→partner) and Y-score (partner→ATP9B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.352	+1.000	.044	.033	3	3
COAD	Rad50 →	-0.386	-3.000	<.001	.034	3	3
COAD	Caspase-7-cleavedD198 →	+1.509	+2.824	<.001	.034	3	3
UCEC	A-Raf_pS299 →	-0.076	-1.247	.022	.041	3	2
UCEC	JNK_pT183_Y185 →	-0.101	-1.152	.031	.048	3	2
UCEC	MSH2 →	-0.312	-1.494	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Akt_pT308 by ATP9B expression — UCEC

Explore this box plot interactively →