ATP8B5P

Across TCGA patient cohorts, ATP8B5P mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP8B5P-associated genes across cancer lineages are ERK2, p38-MAPK_pT180_Y182, and eEF2. Each is linked with ATP8B5P in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP8B5P-to-partner and partner-to-ATP8B5P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ATP8B5P-low versus ATP8B5P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B5P→partner) and Y-score (partner→ATP8B5P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.230	+1.662	<.001	.011	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.485	-1.986	.002	.003	3	2
UCEC	eEF2 →	+0.436	+3.700	<.001	.001	3	1
UCEC	EGFR_pY1068 →	-0.338	-2.392	<.001	<.001	3	1
UCEC	eIF4E →	+0.226	+2.392	.002	<.001	3	1
UCEC	A-Raf_pS299 →	-0.180	-2.584	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ERK2 by ATP8B5P expression — UCEC

Explore this box plot interactively →