ATP8B3

Across TCGA patient cohorts, ATP8B3 mutation is significantly associated with the RNA expression of many other genes, with 2,847 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP8B3-associated genes across cancer lineages are CENPH, TIPIN, and CDADC1. Each is linked with ATP8B3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP8B3-to-partner and partner-to-ATP8B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPH grouped by ATP8B3-low versus ATP8B3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B3→partner) and Y-score (partner→ATP8B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CENPH →	+0.557	+1.682	.002	.007	3	4
COAD	TIPIN →	+0.638	+3.087	<.001	<.001	3	4
UCEC	CDADC1 →	+0.356	+2.234	<.001	.001	3	4
UCEC	CHEK1 →	+0.494	+2.108	.001	.002	3	4
UCEC	CHAF1A →	+0.500	+1.606	<.001	.001	3	4
UCEC	CENPU →	+0.552	+1.891	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,847 associations by consensus.

CENPH by ATP8B3 expression — SKCM

Explore this box plot interactively →