ATP8B3

Across TCGA patient cohorts, ATP8B3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP8B3-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and Cyclin-B1. Each is linked with ATP8B3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP8B3-to-partner and partner-to-ATP8B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ATP8B3-low versus ATP8B3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B3→partner) and Y-score (partner→ATP8B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.005	+3.338	<.001	.004	3	3
UCEC	PCNA →	+0.206	+1.514	.005	.015	3	2
UCEC	Cyclin-B1 →	+0.557	+2.000	.003	.009	3	2
UCEC	HER3_pY1289 →	+0.062	+1.894	.035	.030	3	2
UCEC	NF-kB-p65_pS536 →	-0.317	-2.312	.041	.005	3	2
UCEC	p70-S6K_pT389 →	-0.174	-1.700	.007	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Caspase-7-cleavedD198 by ATP8B3 expression — COAD

Explore this box plot interactively →