ATP8B3

Across TCGA cell cohorts, ATP8B3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,870 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP8B3-associated GO terms across cancer lineages are Actin filament depolymerization, Protein depolymerization, and Keratinocyte development. Each is linked with ATP8B3 in more than 11 cancer types. Because this analysis shows association rather than direction, both ATP8B3-to-partner and partner-to-ATP8B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by ATP8B3-low versus ATP8B3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B3→partner) and Y-score (partner→ATP8B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.219	+2.030	.002	<.001	3	12
BREAST	Protein depolymerization →	+0.131	+1.419	<.001	<.001	3	12
SOFT_TISSUE	Keratinocyte development →	+0.649	+1.358	.004	.002	3	12
URINARY_TRACT	Peptidyl-lysine oxidation →	+1.487	+1.868	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Response to molecule of fungal origin →	-1.513	-1.930	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Cellular response to molecule of fungal origin →	-1.513	-1.930	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,870 associations by consensus.

Actin filament depolymerization by ATP8B3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →