ATP8B3

Across TCGA cell cohorts, ATP8B3 mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP8B3-associated genes across cancer lineages are OR5V1, OR12D2, and GLRA2. Each is linked with ATP8B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP8B3-to-partner and partner-to-ATP8B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5V1 grouped by ATP8B3-low versus ATP8B3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B3→partner) and Y-score (partner→ATP8B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR5V1 →	+0.006	+3.240	.002	.004	3	2
STOMACH	OR12D2 →	+0.200	+3.432	.004	.008	3	2
LUNG_NSCLC_LUAD	GLRA2 →	+0.023	+4.029	<.001	.009	3	2
BREAST	OR1L3 →	+0.022	+5.169	<.001	.005	3	2
PANCREAS	MYF5 →	+0.016	+5.000	<.001	.006	3	1
PANCREAS	OR10G9 →	+0.030	+5.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

OR5V1 by ATP8B3 expression — SKIN

Explore this box plot interactively →