ATP8A1

Across TCGA pan-cancer cohorts, ATP8A1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ATP8A1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ATP8A1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ATP8A1 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, CCRCC, and LUAD are the cancer types where ATP8A1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP8A1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−0.364	<.001	7	view →
CCRCC	Male	All	+0.457	<.001	6	view →
LUAD	Male	III,IV	−0.440	<.001	6	view →
PDAC	Male	All	−0.904	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ATP8A1–COAD

Open the COAD breakdown →