ATP7B

Across TCGA patient cohorts, ATP7B mutation is significantly associated with the RNA expression of many other genes, with 4,833 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP7B-associated genes across cancer lineages are PHF5A, GPHN, and TAF13. Each is linked with ATP7B in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP7B-to-partner and partner-to-ATP7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF5A grouped by ATP7B-low versus ATP7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP7B→partner) and Y-score (partner→ATP7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF5A →	+0.471	+2.662	<.001	<.001	3	4
COAD	GPHN →	+0.725	+3.472	<.001	.002	3	4
UCEC	TAF13 →	+0.525	+1.584	<.001	<.001	3	4
UCEC	MZT1 →	+0.566	+1.606	<.001	<.001	3	4
UCEC	CORT →	+0.397	+1.850	<.001	.002	3	4
UCEC	CENPU →	+0.583	+1.797	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,833 associations by consensus.

PHF5A by ATP7B expression — UCEC

Explore this box plot interactively →