ATP7B

Across TCGA patient cohorts, ATP7B mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP7B-associated genes across cancer lineages are GAPDH, Cyclin-B1, and MEK1. Each is linked with ATP7B in more than 4 cancer types. Because this analysis shows association rather than direction, both ATP7B-to-partner and partner-to-ATP7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ATP7B-low versus ATP7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP7B→partner) and Y-score (partner→ATP7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.447	+1.999	.005	.002	3	5
UCEC	Cyclin-B1 →	+0.547	+2.502	.001	.001	3	4
UCEC	MEK1 →	+0.432	+1.999	<.001	<.001	3	3
UCEC	eEF2 →	+0.277	+2.000	.010	.029	3	3
UCEC	ERK2 →	+0.154	+1.662	.008	.010	3	3
UCEC	ATM →	-0.715	-2.273	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

GAPDH by ATP7B expression — UCEC

Explore this box plot interactively →