ATP7B

Across TCGA cell cohorts, ATP7B mutation is significantly associated with the RNA expression of many other genes, with 420 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP7B-associated genes across cancer lineages are SMIM31, PALD1, and PSMG2. Each is linked with ATP7B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP7B-to-partner and partner-to-ATP7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM31 grouped by ATP7B-low versus ATP7B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP7B→partner) and Y-score (partner→ATP7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SMIM31 →	+1.255	+2.628	.004	.002	3	2
SKIN	PALD1 →	+0.765	+3.364	<.001	.002	3	2
LARGE_INTESTINE	PSMG2 →	+0.577	+3.584	<.001	<.001	3	2
LARGE_INTESTINE	GHITM →	+0.401	+2.714	.004	.002	3	2
LARGE_INTESTINE	KLF13 →	+0.867	+3.169	<.001	.006	3	2
LARGE_INTESTINE	C5orf51 →	+0.472	+2.628	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 420 associations by consensus.

SMIM31 by ATP7B expression — LARGE_INTESTINE

Explore this box plot interactively →