ATP7A

Across TCGA pan-cancer cohorts, ATP7A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ATP7A data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ATP7A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ATP7A expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, LSCC, and PDAC are the cancer types where ATP7A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.944	0.469	.002	14	view →
LSCC	DFS	Quartile	All	0.290	0.883	.004	7	view →
PDAC	OS	Tertile	IV	0.405	0.828	.038	6	view →
HNSC	DFS	Quartile	All	0.893	0.695	.023	3	view →
GBM	DFS	Median	All	0.426	0.209	.019	2	view →
LUAD	OS	Tertile	All	1.000	0.689	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ATP7A–UCEC (DFS)

Open the UCEC breakdown →